Perfect thread timing! We are closing on our new house tomorrow and I am going to try to make the most of the deep two car garage. I'll need to be able to fit the Jeep and wife's van in the garage, but still hoping to make a pretty nice workshop.
One thing I can add to the discussion right off the bat has to do with flooring. At our house in Chicago, I did an epoxy flooring and it was worth its weight in gold. I went with a product called Epoxy Coat. It lays down about 5 times thicker than the big-box store's stuff. All said and done it looked like glass. Made working on the vehicles so nice and cleanup was a breeze. You can add a silica sand to the walkways, but I opted to just lay down heavy duty carpet runners along the walkways.
Edit to add a few pics: