E85 on average nets you about 30% reduction in economy, because of the reduced amount of combustable energy in E85 compared to an equal part of 87/89 octane. The price would have to be 30% cheaper than regular gas to break even on the cost. So it'd have to be even cheaper to actually save money by running E85. I ran E85 in my '13 3.6 Grand Cherokee Trail Hawk when I drove across country from PA to AZ. I got 12 to 14mpg towing a small uhaul trailer at 65-70 mph, burned 3 tanks of it back to back. After that I went back to regular 87 and haven't run e85 since.