My wife and I have both. Her Jeep is the 2 door, and mine is the 4 door. They are very different from each other when driving.
On the street, the two door is much more nimble and easier to park. Turning around and U-Turns are definitely a plus of the 2 door. On the trail, turning around and navigating tight trails, going around trees and rocks there is less worry of body damage. It generally feels much lighter and "zippy". However, cargo space is at a premium. With just the two of us and our dog, once we have all of our gear in place just for even a day trip, it can feel quite crowded and if you are bringing a 3rd or 4th person along, they will be very cramped in the back seat, and you have no space left for anything else.
The 4 door rides much smoother. It doesn't pitch back and forth as much on uneven freeways. The added wheel base adds stability on the trail. When you have to climb over a bank or "lip" it is easier to get the front over first. Although the break over clearance does suffer quite a bit. We can fit all of our camping gear in it and still have room for our dog and a passenger. Turning around on the trail is a bit of a chore. A two point turn is now a 20 point turn.
It really boils down to the fact that the 2 door suits her best and the 4 door lsuits me best. When we do hit the trail, we usually have both.
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