Cologuard is over 90% accurate, according to my Dr. I do one every 2 years, figure it's very unlikely I would get 2 false negatives in a row, and it sure beats the alternative method.
Just for follow-up: I did the PPE pan, filter, and fluid change. Have driven it on a few long trips since then and I did notice the transmission temps were a few degrees lower. More importantly, it is much easier to change the fluid next time.